Intramembrane proteolysis of an extracellular serine protease, epithin/PRSS14, enables its intracellular nuclear function
Abstract Background Epithin/PRSS14, a type II transmembrane serine Action Figure protease, is an emerging target of cancer therapy because of its critical roles in tumor progression and metastasis.In many circumstances, the protease, through its ectodomain shedding, exists as a soluble form and performs its proteolytic functions in extracellular en